Current strategies for knee cartilage repair

被引:62
作者
Kalson, N. S. [1 ]
Gikas, P. D. [1 ]
Briggs, T. W. R. [1 ]
机构
[1] Royal Natl Orthopaed Hosp, Bone Tumour Serv, Stanmore HA7 4LP, Middx, England
关键词
AUTOLOGOUS CHONDROCYTE IMPLANTATION; ARTICULAR-CARTILAGE; MICROFRACTURE TECHNIQUE; CHONDRAL DEFECTS; OSTEOCHONDRITIS-DISSECANS; RANDOMIZED-TRIAL; LESIONS; TRANSPLANTATION; MOSAICPLASTY; INJURIES;
D O I
10.1111/j.1742-1241.2010.02420.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
P>Defects in knee articular cartilage (AC) can cause pain and disability and present the clinician with an extremely challenging clinical situation. This article describes the most up-to-date surgical techniques that aim to repair and/or regenerate symptomatic focal defects in AC, which include arthroscopic debridement, microfracture bone marrow stimulation and autologous osteochondral allografting, with an emphasis on autologous chondrocyte implantation. In the future, refinement of tissue-engineering approaches promises to further improve outcome for these patients.
引用
收藏
页码:1444 / 1452
页数:9
相关论文
共 71 条
[1]  
[Anonymous], 2006, COCHRANE DB SYST REV
[2]   The Microfracture Technique for the Treatment of Full-Thickness Articular Cartilage Lesions of the Knee: Midterm Results [J].
Asik, Mehmet ;
Ciftci, Feyyaz ;
Sen, Cengiz ;
Erdil, Mehmet ;
Atalar, Atacan .
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 2008, 24 (11) :1214-1220
[3]  
BASAD E, 2004, ORTHOP PRAX, V40, P5
[4]   Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI) - 5-year follow-up [J].
Behrens, Peter ;
Bitter, Thomas ;
Kurz, Bodo ;
Russlies, Martin .
KNEE, 2006, 13 (03) :194-202
[5]   Treatment Selection in Articular Cartilage Lesions of the Knee A Systematic Review [J].
Bekkers, Joris E. J. ;
Inklaar, Melanie ;
Saris, Daniel B. F. .
AMERICAN JOURNAL OF SPORTS MEDICINE, 2009, 37 :148S-155S
[6]   A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee [J].
Bentley, G ;
Biant, LC ;
Carrington, RWJ ;
Akmal, M ;
Goldberg, A ;
Williams, AM ;
Skinner, JA ;
Pringle, J .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2003, 85B (02) :223-230
[7]  
Blevins FT, 1998, ORTHOPEDICS, V21, P761
[8]   TREATMENT OF DEEP CARTILAGE DEFECTS IN THE KNEE WITH AUTOLOGOUS CHONDROCYTE TRANSPLANTATION [J].
BRITTBERG, M ;
LINDAHL, A ;
NILSSON, A ;
OHLSSON, C ;
ISAKSSON, O ;
PETERSON, L .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (14) :889-895
[9]   Magnetic resonance imaging appearance of cartilage repair in the knee [J].
Brown, WE ;
Potter, HG ;
Marx, RG ;
Wickiewicz, TL ;
Warren, RF .
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2004, (422) :214-223
[10]   INVITRO SYNTHESIS OF TISSUE-SPECIFIC TYPE-II COLLAGEN BY HEALING CARTILAGE .1. SHORT-TERM REPAIR OF CARTILAGE BY MATURE RABBITS [J].
CHEUNG, HS ;
LYNCH, KL ;
JOHNSON, RP ;
BREWER, BJ .
ARTHRITIS AND RHEUMATISM, 1980, 23 (02) :211-219