Formation of oxidation by-products of the iodinated X-ray contrast medium iomeprol during ozonation

被引：78

作者：

Seitz, Wolfram ^{[2
]}

Jiang, Jia-Qian ^{[1
]}

Schulz, Wolfgang ^{[2
]}

Weber, Walter H. ^{[2
]}

Maier, Dietrich ^{[3
]}

Maier, Matthias ^{[1
]}

机构：

[1] Univ Surrey, Sch Engn C5, Guildford GU2 7XH, Surrey, England

[2] Betriebs & Forschungslaboratorium, Zweckverband Landeswasserversorgung, D-89129 Langenau, Germany

[3] Univ Karlsruhe, Fak Chem Ingenieurwesen & Verfahrenstech, D-76128 Karlsruhe, Germany

来源：

CHEMOSPHERE | 2008年 / 70卷 / 07期

关键词：

chemical analysis; chromatography; environment; iodinated X-ray contrast media; oxidation by-products;

D O I：

10.1016/j.chemosphere.2007.07.081

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The present work describes the investigation of the formation of oxidation by-products of the iodinated X-ray contrast medium (ICM) iomeprol during ozonation in water treatment. Bench-scale investigations revealed that ICM can be partly oxidized during ozonation processes, whereas the ionic diatrizoic acid showed the lowest reactivity. Iomeprol, as a representative of ICM, was not fully mineralized during ozonation. Thus, unknown oxidation by-products were formed. Aqueous solutions of iomeprol were treated by ozonation in order to assess the formation of oxidation by-products. The by-products were characterized by different liquid chromatography methods including detection of sin le-stage mass spectra, product ion mass spectra, and induced in-source fragmentation for analysis of iodine containing oxidation by-products. Aldehyde and carbonyl containing compounds were proposed to be among the stable by-products. A derivatization step confirms that the aldehyde and carbonyl moieties are major functional groups in oxidation by-products of iomeprol. Furthermore, oxidation by-products of iomeprol were detected at the outlet of an ozone reactor at a full-scale waterworks. However, the toxicological relevance of the by-products is a major future research tasks. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1238 / 1246

页数：9

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