Recent progress in defining the role of scavenger receptors in lipid transport, atherosclerosis and host defence

被引：102

作者：

Greaves, DR ^{[1
]}

Gough, PJ ^{[1
]}

Gordon, S ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

CURRENT OPINION IN LIPIDOLOGY | 1998年 / 9卷 / 05期

关键词：

D O I：

10.1097/00041433-199810000-00006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Scavenger receptors bind and internalize modified lipoproteins. There are several different classes of scavenger receptors in mammalian cells and their relative contribution to lipid transport in normal physiology and pathological conditions such as atherosclerosis has been the subject of intense investigation. Mice with a disruption in the macrophage scavenger receptor SR-A gene exhibit a reduced size of atherosclerotic lesions and also exhibit an enhanced susceptibility to pathogens and endotoxic shock. In addition to their role in lipid transport, scavenger receptors play important roles in host defence and in the regulation of acquired immunity. Recent progress in delineating the mechanisms by which oxidized LDL effects changes in gene expression will be reviewed. Curr Opin Lipidol 9:425-432. (C) 1998 Lippincott Williams & Wilkins

引用

页码：425 / 432

页数：8

共 63 条

[11] CLONING OF A NOVEL BACTERIA-BINDING RECEPTOR STRUCTURALLY RELATED TO SCAVENGER RECEPTORS AND EXPRESSED IN A SUBSET OF MACROPHAGES [J].

ELOMAA, O ;

KANGAS, M ;

SAHLBERG, C ;

TUUKKANEN, J ;

SORMUNEN, R ;

LIAKKA, A ;

THESLEFF, I ;

KRAAL, G ;

TRYGGVASON, K .

CELL, 1995, 80 (04) :603-609

[12] Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells [J].

Franc, NC ;

Dimarcq, JL ;

Lagueux, M ;

Hoffmann, J ;

Ezekowitz, RAB .

IMMUNITY, 1996, 4 (05) :431-443

[13] DIVALENT CATION-INDEPENDENT MACROPHAGE ADHESION INHIBITED BY MONOCLONAL-ANTIBODY TO MURINE SCAVENGER RECEPTOR [J].

FRASER, I ;

HUGHES, D ;

GORDON, S .

NATURE, 1993, 364 (6435) :343-345

[14]

Gough PJ, 1998, J LIPID RES, V39, P531

[15]

GOUGH PJ, 1998, IN PRESS ARTERIOSCLE

[16] Influence of lipoteichoic acid structure on recognition by the macrophage scavenger receptor [J].

Greenberg, JW ;

Fischer, W ;

Joiner, KA .

INFECTION AND IMMUNITY, 1996, 64 (08) :3318-3325

[17] RECOGNITION AND PLASMA-CLEARANCE OF ENDOTOXIN BY SCAVENGER RECEPTORS [J].

HAMPTON, RY ;

GOLENBOCK, DT ;

PENMAN, M ;

KRIEGER, M ;

RAETZ, CRH .

NATURE, 1991, 352 (6333) :342-344

[18]

Han JH, 1998, AM J PATHOL, V152, P1647

[19] The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock [J].

Haworth, R ;

Platt, N ;

Keshav, S ;

Hughes, D ;

Darley, E ;

Suzuki, H ;

Kurihara, Y ;

Kodama, T ;

Gordon, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (09) :1431-1439

[20] High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1) [J].

Hoshikawa, H ;

Sawamura, T ;

Kakutani, M ;

Aoyama, T ;

Nakamura, T ;

Masaki, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 245 (03) :841-846

← 1 2 3 4 5 6 7 →