Therapeutic strategies: Surgery for human papillomavirus-associated oropharyngeal carcinoma

被引：3
作者：
Mclean, Timothy [1 ]
Fitzgerald, Conall [1 ]
Boyle, Jay O. [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Head & Neck Serv, Dept Surg, 1275 York Ave, New York, NY 10065 USA
来源：
JOURNAL OF SURGICAL ONCOLOGY | 2021年 / 124卷 / 06期
关键词：
deintensification; HPV; oropharynx; surgery; TOS; SQUAMOUS-CELL CARCINOMA; TRANSORAL ROBOTIC SURGERY; COST-EFFECTIVENESS ANALYSIS; UNKNOWN PRIMARY TUMORS; LOCALLY ADVANCED HEAD; SALVAGE SURGERY; LASER MICROSURGERY; FUNCTIONAL OUTCOMES; RADIATION-THERAPY; SURGICAL SALVAGE;
D O I：
10.1002/jso.26695
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Treatment of oropharyngeal cancer (OPC) has undergone considerable evolution since the discovery of human papillomavirus (HPV)-associated OPC. It is widely understood that HPV OPC affects a younger population and standard treatment offers improved oncologic outcomes compared with non-HPV OPC but can cause significant toxicities and long-term side effects. Surgery for treatment de-escalation is an active area of research. The purpose of this review is to explore surgery as it relates to the treatment of HPV OPC with a focus on the evolution of treatment, rationale for surgery, surgical techniques, outcomes, and the role of surgery in de-escalation of treatment.
引用
收藏
页码：935 / 944
页数：10
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