Chemistry and biology of salicylihalamide A and related compounds

被引：237

作者：

Yet, L ^{[1
]}

机构：

[1] Albany Mol Res Inc, Dept Med Chem, Albany, NY 12212 USA

来源：

CHEMICAL REVIEWS | 2003年 / 103卷 / 11期

关键词：

D O I：

10.1021/cr030035s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review discusses a new class of salicylate macrolactone enamide natural products with a new mode of biological activity. Total syntheses of salicylihalamide A and its congeners have led to the identification of further classes of compounds aimed at developing mammalian V-ATPase as a therapeutic target. Since the initial discovery of these compounds, academic laboratories around the world have taken a keen interest in the unique chemistry and biology of these novel new chemical entities.

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页码：4283 / 4306

页数：24

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