Mouse Tumor-Bearing Models as Preclinical Study Platforms for Oral Squamous Cell Carcinoma

被引：59

作者：

Li, Qiang ^{[1
]}

Dong, Heng ^{[1
,2
]}

Yang, Guangwen ^{[1
]}

Song, Yuxian ^{[1
]}

Mou, Yongbin ^{[1
,2
]}

Ni, Yanhong ^{[1
]}

机构：

[1] Nanjing Univ, Nanjing Stomatol Hosp, Med Sch, Cent Lab, Nanjing, Peoples R China

[2] Nanjing Univ, Nanjing Stomatol Hosp, Med Sch, Dept Oral Implantol, Nanjing, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2020年 / 10卷

关键词：

mouse models; OSCC; chemical carcinogen-induced; transplanted; xenograft; syngeneic; HPV; genetically engineered models; LYMPH-NODE METASTASIS; HPV-RELATED HEAD; 4-NITROQUINOLINE; 1-OXIDE; ANIMAL-MODELS; IN-VITRO; 4-HYDROXYAMINOQUINOLINE; INITIATING ACTIVITY; THERAPEUTIC TARGET; XENOGRAFT MODEL; GENE-EXPRESSION;

D O I：

10.3389/fonc.2020.00212

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Preclinical animal models of oral squamous cell carcinoma (OSCC) have been extensively studied in recent years. Investigating the pathogenesis and potential therapeutic strategies of OSCC is required to further progress in this field, and a suitable research animal model that reflects the intricacies of cancer biology is crucial. Of the animal models established for the study of cancers, mouse tumor-bearing models are among the most popular and widely deployed for their high fertility, low cost, and molecular and physiological similarity to humans, as well as the ease of rearing experimental mice. Currently, the different methods of establishing OSCC mouse models can be divided into three categories: chemical carcinogen-induced, transplanted and genetically engineered mouse models. Each of these methods has unique advantages and limitations, and the appropriate application of these techniques in OSCC research deserves our attention. Therefore, this review comprehensively investigates and summarizes the tumorigenesis mechanisms, characteristics, establishment methods, and current applications of OSCC mouse models in published papers. The objective of this review is to provide foundations and considerations for choosing suitable model establishment methods to study the relevant pathogenesis, early diagnosis, and clinical treatment of OSCC.

引用

页数：21

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