Cell Fate Decisions: The Role of Transcript on Factors in Early B-cell Development and Leukemia

被引：21

作者：

Fischer, Ute ^{[1
]}

Yang, Jun J. ^{[2
]}

Ikawa, Tomokatsu ^{[3
]}

Hein, Daniel ^{[1
]}

Vicente-Duenas, Carolina ^{[4
]}

Borkhardt, Arndt ^{[1
]}

Sanchez-Garcia, Isidro ^{[4
,5
]}

机构：

[1] Heinrich Heine Univ, Med Fac, Dept Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany

[2] St Jude Childrens Res Hosp, Comprehens Canc Ctr, Hematol Malignancies Programme, 332 N Lauderdale St, Memphis, TN 38105 USA

[3] Tokyo Univ Sci, Res Inst Biomed Sci, Div Immunobiol, Noda, Chiba, Japan

[4] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain

[5] Univ Salamanca, CSIC, Inst Biol Mol & Celular Canc, Expt Therapeut & Translat Oncol Program, Salamanca, Spain

来源：

BLOOD CANCER DISCOVERY | 2020年 / 1卷 / 03期

基金：

日本学术振兴会;

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; INFECTION EXPOSURE; PRENATAL ORIGIN; COMMITMENT; FUSION; ETV6; SUSCEPTIBILITY; PROGENITOR; MUTATIONS; EBF1;

D O I：

10.1158/2643-3230.BCD-20-0011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

B cells are an integral part of the adaptive immune system and regulate innate immunity. Derived from hematopoietic stem cells, B cells mature through a series of cell fate decisions. Complex transcriptional circuits form and dissipate dynamically during these lineage restrictions. Genomic aberrations of involved transcription factors underlie various B-cell disorders. Acquired somatic aberrations are associated with cancer, whereas germline variations predispose to both malignant and nonmalignant diseases. We review the opposing role of transcription factors during B-cell development in health and disease. We focus on early B-cell leukemia and discuss novel causative gene-environment cooperation and their implications for precision medicine. Childhood leukemia is frequently initiated during fetal hematopoiesis. Clinical silent preleukemic clones are detectable in cord blood of a large number of healthy newborns. These predisposing alterations cooperate with environmental factors to trigger leukemia onset. Understanding of the underlying principles is a prerequisite for the development of measures to prevent leukemia in children.

引用

页码：224 / 233

页数：10

共 75 条

[1] Upregulation of flt3 expression within the bone marrow Lin-Sca1+c-kit+ stem cell compartment is accompanied by loss of self-renewal capacity [J].

Adolfsson, J ;

Borge, OJ ;

Bryder, D ;

Theilgaard-Mönch, K ;

Åstrand-Grundström, I ;

Sitnicka, E ;

Sasaki, Y ;

Jacobsen, SEW .

IMMUNITY, 2001, 15 (04) :659-669

[2] Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential:: A revised road map for adult blood lineage commitment [J].

Adolfsson, J ;

Månsson, R ;

Buza-Vidas, N ;

Hultquist, A ;

Liuba, K ;

Jensen, CT ;

Bryder, D ;

Yang, LP ;

Borge, OJ ;

Thoren, LAM ;

Anderson, K ;

Sitnicka, E ;

Sasaki, Y ;

Sigvardsson, M ;

Jacobsen, SEW .

CELL, 2005, 121 (02) :295-306

[3] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].

Akashi, K ;

Traver, D ;

Miyamoto, T ;

Weissman, IL .

NATURE, 2000, 404 (6774) :193-197

[4] The genetic basis and cell of origin of mixed phenotype acute leukaemia [J].

Alexander, Thomas B. ;

Gu, Zhaohui ;

Iacobucci, Ilaria ;

Dickerson, Kirsten ;

Choi, John K. ;

Xu, Beisi ;

Payne-Turner, Debbie ;

Yoshihara, Hiroki ;

Loh, Mignon L. ;

Horan, John ;

Buldini, Barbara ;

Basso, Giuseppe ;

Elitzur, Sarah ;

de Haas, Valerie ;

Zwaan, C. Michel ;

Yeoh, Allen ;

Reinhardt, Dirk ;

Tomizawa, Daisuke ;

Kiyokawa, Nobutaka ;

Lammens, Tim ;

De Moerloose, Barbara ;

Catchpoole, Daniel ;

Hori, Hiroki ;

Moorman, Anthony ;

Moore, Andrew S. ;

Hrusak, Ondrej ;

Meshinchi, Soheil ;

Orgel, Etan ;

Devidas, Meenakshi ;

Borowitz, Michael ;

Wood, Brent ;

Heerema, Nyla A. ;

Carrol, Andrew ;

Yang, Yung-Li ;

Smith, Malcolm A. ;

Davidsen, Tanja M. ;

Hermida, Leandro C. ;

Gesuwan, Patee ;

Marra, Marco A. ;

Ma, Yussanne ;

Mungall, Andrew J. ;

Moore, Richard A. ;

Jones, Steven J. M. ;

Valentine, Marcus ;

Janke, Laura J. ;

Rubnitz, Jeffrey E. ;

Pui, Ching-Hon ;

Ding, Liang ;

Liu, Yu ;

Zhang, Jinghui .

NATURE, 2018, 562 (7727) :373-+

[5] MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia [J].

Armstrong, SA ;

Staunton, JE ;

Silverman, LB ;

Pieters, R ;

de Boer, ML ;

Minden, MD ;

Sallan, SE ;

Lander, ES ;

Golub, TR ;

Korsmeyer, SJ .

NATURE GENETICS, 2002, 30 (01) :41-47

[6] Inherited susceptibility to pre B-ALL caused by germline transmission of PAX5 c. 547G>A [J].

Auer, F. ;

Rueschendorf, F. ;

Gombert, M. ;

Husemann, P. ;

Ginzel, S. ;

Izraeli, S. ;

Harit, M. ;

Weintraub, M. ;

Weinstein, O. Y. ;

Lerer, I. ;

Stepensky, P. ;

Borkhardt, A. ;

Hauer, J. .

LEUKEMIA, 2014, 28 (05) :1136-1138

[7] Homozygous transcription factor 3 gene (TCF3) mutation is associated with severe hypogammaglobulinemia and B-cell acute lympho blastic leukemia [J].

Ben-Ali, Meriem ;

Yang, Jing ;

Chan, Koon Wing ;

Ben-Mustapha, Imen ;

Mekki, Najla ;

Benabdesselem, Chaouki ;

Mellouli, Fethi ;

Bejaoui, Mohamed ;

Yang, Wanling ;

Aissaoui, Lamia ;

Lau, Yu Lung ;

Barbouche, Mohamed-Ridha .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (04) :1191-+

[8] A recurrent dominant negative E47 mutation causes agammaglobulinemia and BCR- B cells [J].

Boisson, Bertrand ;

Wang, Yong-Dong ;

Bosompem, Amma ;

Ma, Cindy S. ;

Lim, Annick ;

Kochetkov, Tatiana ;

Tangye, Stuart G. ;

Casanova, Jean-Laurent ;

Conley, Mary Ellen .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (11) :4781-4785

[9] The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth [J].

Bossen, Claudia ;

Murre, Caroline S. ;

Chang, Aaron N. ;

Mansson, Robert ;

Rodewald, Hans-Reimer ;

Murre, Cornelis .

NATURE IMMUNOLOGY, 2015, 16 (07) :775-+

[10] Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors [J].

Boulianne, Bryant ;

Robinson, Mark E. ;

May, Philippa C. ;

Castellano, Leandro ;

Blighe, Kevin ;

Thomas, Jennifer ;

Reid, Alistair ;

Muschen, Markus ;

Apperley, Jane F. ;

Stebbing, Justin ;

Feldhahn, Niklas .

CELL REPORTS, 2017, 18 (07) :1687-1698

← 1 2 3 4 5 6 7 8 →