3D spatial genome organization in the nervous From and to disease

被引：13

作者：

Fujita, Yuki ^{[1
,2
]}

Pather, Sarshan R. ^{[1
,3
]}

Ming, Guo-li ^{[1
,4
,5
,6
]}

Song, Hongjun ^{[1
,4
,6
,7
]}

机构：

[1] Univ Penn, Dept Neurosci, Mahoney Inst Neurosci, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Shimane Univ, Fac Med, Dept Dev Biol, Izumo, Shimane 6938501, Japan

[3] Univ Penn, Cell & Mol Biol Grad Grp, Philadelphia, PA 19104 USA

[4] Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

[5] Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA

[6] Univ Penn, Inst Regenerat Med, Philadelphia, PA 19104 USA

[7] Univ Penn, Epigenet Inst, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

NEURON | 2022年 / 110卷 / 18期

基金：

美国国家卫生研究院;

关键词：

CHROMATIN ORGANIZATION; CENTROMERIC SATELLITE; NUCLEAR ARCHITECTURE; SENSORY EXPERIENCE; GENE-REGULATION; CELL IDENTITY; DNA; DOMAINS; COHESIN; REORGANIZATION;

D O I：

10.1016/j.neuron.2022.06.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chromatin is organized into multiscale three-dimensional structures, including chromosome territories, A/B compartments, topologically associating domains, and chromatin loops. This hierarchically organized genomic architecture regulates gene transcription, which, in turn, is essential for various biological pro-cesses during brain development and adult plasticity. Here, we review different aspects of spatial genome organization and their functions in regulating gene expression in the nervous system, as well as their dysre-gulation in brain disorders. We also highlight new technologies to probe and manipulate chromatin architec-ture and discuss how investigating spatial genome organization can lead to a better understanding of the nervous system and associated disorders.

引用

页码：2902 / 2915

页数：14

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