Manganese Catalyzed α-Alkylation of Nitriles with Primary Alcohols

被引：107

作者：

Jana, Akash ^{[1
]}

Reddy, C. Bal ^{[1
]}

Maji, Biplab ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Mohanpur 741246, India

来源：

ACS CATALYSIS | 2018年 / 8卷 / 10期

关键词：

homogeneous catalysis; bifunctional ligand; borrowing hydrogen; alcohols; manganese; PINCER COMPLEXES; BORROWING HYDROGEN; N-ALKYLATION; DEHYDROGENATION REACTIONS; SECONDARY ALCOHOLS; BOND FORMATION; C-ALKYLATION; AMINES; KETONES; ARYLACETONITRILES;

D O I：

10.1021/acscatal.8b02998

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The manganese(I) complex bearing a bidentate hydrazone ligand efficiently catalyzes the alpha-alkylations of nitrile using primary alcohols as alkylating agents. alpha-Functionalized nitriles were selectively obtained in good to excellent yields. The reaction is environmentally benign, producing water as the sole byproduct. Both benzylic and aliphatic alcohols could be used and functional groups were tolerated.

引用

页码：9226 / 9231

页数：11

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