Analysis of the anti-inflammatory properties of Rosmarinus officinalis L. in mice

被引：75
作者：
Beninca, Jucelia Pizzetti [1 ]
Dalmarco, Juliana Bastos [2 ]
Pizzolatti, Moacir Geraldo [2 ]
Froede, Tania Silvia [1 ]
机构：
[1] Univ Fed Santa Catarina, Ctr Hlth Sci, Dept Clin Anal, BR-88040970 Florianopolis, SC, Brazil
[2] Univ Fed Santa Catarina, Ctr Phys & Math Sci, Dept Chem, BR-88040970 Florianopolis, SC, Brazil
来源：
FOOD CHEMISTRY | 2011年 / 124卷 / 02期
关键词：
Rosmarinus officinalis L; Anti-inflammatory activity; Pleurisy; Cytokines; Myeloperoxidase; Nitric oxide; NITRIC-OXIDE SYNTHASE; FACTOR-KAPPA-B; ESSENTIAL OIL; ACID; CYCLOOXYGENASE-2; MYELOPEROXIDASE; ANTIOXIDANTS; TRITERPENES; ACTIVATION; CARNOSOL;
D O I：
10.1016/j.foodchem.2010.06.056
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The aim of this study was to investigate the anti-inflammatory effects of the crude extract (CE) of Rosmarinus officinalis L its derived fractions: hexane (HEX), ethyl acetate (AcOEt), and ethanolic (ET), and isolated compounds: carnosol, betulinic acid and ursolic acid, in the mouse pleurisy model induced by carrageenan. Swiss mice were used in the in vivo experiments. The CE and its derived fractions and isolated compounds inhibited leukocytes, exudation, interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF-alpha) levels, myeloperoxidase activity (MPO), and nitrite/nitrate production (NOx) (p < 0.05). R. officinalis L showed an important anti-inflammatory activity by inhibition not only of leukocytes and exudation, but also of a pro-inflammatory enzyme and mediators (MPO, NOx, IL-1 beta, and TNF-alpha). The present study showed that carnosol, betulinic acid and ursolic acid compounds could be responsible for this anti-inflammatory effect. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：468 / 475
页数：8
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