Coronary heart disease in HIV-infected individuals

被引:393
|
作者
Currier, JS
Taylor, A
Boyd, F
Dezii, CM
Kawabata, H
Burtcel, B
Maa, JF
Hodder, S
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, CHS, Los Angeles, CA 90095 USA
[2] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA
[3] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA
[4] Bristol Myers Squibb Co, Princeton, NJ USA
关键词
coronary heart disease; HIV infection; CHD incidence;
D O I
10.1097/00126334-200308010-00012
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
It is currently unknown whether there is an increased risk of coronary heart disease (CHD) in patients with HIV infection. In addition, the contribution of antiretroviral therapy (ART) to CHD risk has not been quantified. We reviewed administrative claims data for HIV-infected and -uninfected individuals from the California Medicaid population and compared the incidence of and relative risk (RR) for CHD using log-linear regression analyses between groups. The association between exposure to ART and CHD incidence was also assessed. Of 3,083,209 individuals analyzed, 28,513 were HIV-infected. The incidence of CHD among young men (up to age 34) and women (up to age 44) with HIV infection was significantly higher than that among non-HIV-infected individuals. The covariate-adjusted RR for the development of CHD in individuals receiving ART compared with those not receiving ART was 2.06 (P < 0.001) in HIV-infected individuals aged 18-33 years. There were no statistically significant associations between ART exposure and CHD in other age groups. CHD incidence appears accelerated among young HIV-infected individuals. Strategies to reduce CHD risk should be incorporated into HIV primary care.
引用
收藏
页码:506 / 512
页数:7
相关论文
共 50 条
  • [1] Coronary Heart Disease in HIV-Infected Patients
    Arzhakova, Maria A.
    Shekhovtsova, Tatyana A.
    Duplyakov, Dmitry, V
    RATIONAL PHARMACOTHERAPY IN CARDIOLOGY, 2019, 15 (06) : 900 - 905
  • [2] Epidemiology of coronary heart disease in HIV-infected versus uninfected individuals in developed countries
    Lang, Sylvie
    Boccara, Franck
    Mary-Krause, Murielle
    Cohen, Ariel
    ARCHIVES OF CARDIOVASCULAR DISEASES, 2015, 108 (03) : 206 - 215
  • [3] Coronary heart disease in HIV-infected patients.
    Glesby M.J.
    Current HIV/AIDS Reports, 2005, 2 (2) : 68 - 73
  • [4] Coronary heart disease risk, dyslipidemia, and management in HIV-infected persons
    Fichtenbaum, CJ
    HIV CLINICAL TRIALS, 2004, 5 (06): : 416 - 433
  • [5] Inflammation, Coagulation and Cardiovascular Disease in HIV-Infected Individuals
    Duprez, Daniel A.
    Neuhaus, Jacqueline
    Kuller, Lewis H.
    Tracy, Russell
    Belloso, Waldo
    De Wit, Stephane
    Drummond, Fraser
    Lane, H. Clifford
    Ledergerber, Bruno
    Lundgren, Jens
    Nixon, Daniel
    Paton, Nicholas I.
    Prineas, Ronald J.
    Neaton, James D.
    PLOS ONE, 2012, 7 (09):
  • [6] Vaccination in HIV-infected individuals
    Le Corre, Nicole
    Autran, Brigitte
    FUTURE VIROLOGY, 2012, 7 (01) : 85 - 102
  • [7] The respiratory microbiome of HIV-infected individuals
    Lawani, M. B.
    Morris, A.
    EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2016, 14 (08) : 719 - 729
  • [8] Use of Abacavir and Risk of Cardiovascular Disease Among HIV-Infected Individuals
    Marcus, Julia L.
    Neugebauer, Romain S.
    Leyden, Wendy A.
    Chao, Chun R.
    Xu, Lanfang
    Quesenberry, Charles P., Jr.
    Klein, Daniel B.
    Towner, William J.
    Horberg, Michael A.
    Silverberg, Michael J.
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2016, 71 (04) : 413 - 419
  • [9] Endodontic infection in HIV-infected individuals: An overview
    Fontes, Tatiana Vasconcellos
    Marques, Fabio Vidal
    Goncalves, Lucio Souza
    ENDO-ENDODONTIC PRACTICE TODAY, 2015, 9 (01): : 15 - 23
  • [10] Determinants of Smoking and Quitting in HIV-Infected Individuals
    Regan, Susan
    Meigs, James B.
    Grinspoon, Steven K.
    Triant, Virginia A.
    PLOS ONE, 2016, 11 (04):