Vacuolating toxin production in clinical isolates of Helicobacter pylori with different vacA genotypes

被引：70

作者：

Wang, HJ ^{[1
]}

Kuo, CH ^{[1
]}

Yeh, AAM ^{[1
]}

Chang, PCL ^{[1
]}

Wang, WC ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Life Sci, Hsinchu 300, Taiwan

来源：

JOURNAL OF INFECTIOUS DISEASES | 1998年 / 178卷 / 01期

关键词：

D O I：

10.1086/515600

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A vacuolating cytotoxin encoded by vacA in Helicobacter pylori is known as a potential virulent determinant. The relationship between different vacA alleles, vacuolating ability, and H. pylori-related diseases was investigated. Genetic analysis of 119 isolates from Taiwanese patients revealed that 104 strains were s1a/m2, 13 strains were characterized as the s1a/m1T type, which was more homologous to the s1a/m1 strains, and 2 were characterized as the s1a/m1Tm2 chimeric type. Production of high-grade cytotoxin among 11 strains with s1a/m1T was higher (72.7%) than among 66 strains with s1a/m2 (21.2%) (P < .01). Peptic ulcer occurred in 76.9% of 13 patients with s1a/m1T strains compared with 46.2% of 104 patients with s1a/m2 strains (P < .05). These results suggest that s1a/m1T strains are associated with increased cytotoxic activity and higher ulcer prevalence than are s1a/m2 strains.

引用

页码：207 / 212

页数：6

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