Supercooling Self-Assembly of Magnetic Shelled Core/Shell Supraparticles

Molecular self-asserribly has emerged as a powerful technique for controlling the structure and properties of core/shell structured supraparticles. However, drag-loading capacities and therapeutic effects of self,assembled magnetic core/shell nanocarriers with magnetic nanoparticles in the core are limited by the intervention of the outer organic or inorganic shell, the aggregation of superparamagnetic nanoparticles, the narrowed inner cavity, etc. Here; we present a self-assembly approach based on rebalancing hydrogen bonds between components under a supercooling process to form a new core/shell nanoscale supraparticle with magnetic nanoparticles as the shell and a polysaccharide as a core. Compared with conventional iron aide nanoparticles, this magnetic shelled core/shell nanoparticle possesses an optimized inner cavity and a loss-free outer magnetic property. Furthermore, we find that the drug-loaded magnetic shelled nanocarriers Showed interesting in vitro release behaviors at different pH conditions, including "swelling-broken", "dissociating-broken', and "bursting-broken" :modes. Our experiments demonstrate the novel design of the multifunctional hybrid nanostructure and provide a considerable potential for the biomedical applications.