Formulation Development and Characterization of 5-Fluorouracil Based Microbeads Using Hydroxypropyl-β-Cyclodextrin for Innovative Drug Delivery

被引：0
作者：
Nasir, Bushra [1 ]
Ranjha, Nazar M. [1 ]
Hanif, Muhammad [1 ]
Abbas, Ghulam [1 ,2 ]
Razzaq, Rabia [1 ]
机构：
[1] Bahauddin Zakariya Univ Multan, Fac Pharm, Multan, Pakistan
[2] Govt Coll Univ Faisalabad, Fac Pharmaceut Sci, Faisalabad, Pakistan
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2016年 / 35卷
关键词：
crosslinking; 5-fluorouracil; FTIR; hydroxypropyl-beta-cyclodextrin; microbeads; CONTROLLED-RELEASE; MICROSPHERES; ALGINATE; CHITOSAN; SYSTEMS; BEADS; ETHYLCELLULOSE; NANOPARTICLES; DICLOFENAC; COMPLEX;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of the study was to formulate microbeads of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) using sodium alginate (SA) containing 5-fluorouracil (5-FU) by emulsion crosslinking technique. The microbeads were prepared by varying the concentration of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and sodium alginate (SA). The prepared microbeads were evaluated for swelling degree, drug entrapment, scanning electron microscopy (SEM), Fourier transforms infrared spectroscopy (FTIR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). SEM confirms the slight rough nature of microbeads. No significant drug polymer interactions were observed in FTIR studies. XRD and DSC revealed amorphous nature of drug after being entrapped. Gas chromatography confirms the absence of glutaraldehyde residue. The drug release shows excellent sustained drug release pattern.
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收藏
页码：1092 / 1101
页数：10
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