Zebrafish as a new animal model for movement disorders

被引：95

作者：

Flinn, Laura ^{[1
,2
]}

Bretaud, Sandrine ^{[3
]}

Lo, Christine ^{[1
,2
]}

Ingham, Phillip W. ^{[2
]}

Bandmann, Oliver ^{[1
,2
]}

机构：

[1] Univ Sheffield, Acad Neurol Unit, Sch Med, Sheffield S10 2RX, S Yorkshire, England

[2] Univ Sheffield, MRC, Ctr Dev & Biomed Genet, Sheffield S10 2RX, S Yorkshire, England

[3] Univ Lyon 1, Inst Biol & Chim Prot, F-69365 Lyon, France

来源：

JOURNAL OF NEUROCHEMISTRY | 2008年 / 106卷 / 05期

基金：

英国医学研究理事会;

关键词：

dopamine; Huntington's disease; movement disorders; Parkinson's disease; zebrafish;

D O I：

10.1111/j.1471-4159.2008.05463.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The zebrafish, long recognized as a model organism for the analysis of basic developmental processes, is now also emerging as an alternative animal model for human diseases. This review will first provide an overview of the particular characteristics of zebrafish in general and their dopaminergic nervous system in particular. We will then summarize all work undertaken so far to establish zebrafish as a new animal model for movement disorders and will finally emphasize its particular strength - amenability to high throughput in vivo drug screening.

引用

页码：1991 / 1997

页数：7

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