Youth-Onset Type 2 Diabetes Consensus Report: Current Status, Challenges, and Priorities

被引：286

作者：

Nadeau, Kristen J. ^{[1
,2
]}

Anderson, Barbara J. ^{[3
]}

Berg, Erika G. ^{[4
]}

Chiang, Jane L. ^{[4
]}

Chou, Hubert ^{[5
]}

Copeland, Kenneth C. ^{[6
,7
]}

Hannon, Tamara S. ^{[8
]}

Huang, Terry T. -K. ^{[9
]}

Lynch, Jane L. ^{[10
]}

Powell, Jeff ^{[11
]}

Sellers, Elizabeth ^{[12
]}

Tamborlane, William V. ^{[13
,14
]}

Zeitler, Philip ^{[1
,2
]}

机构：

[1] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA

[2] Childrens Hosp Colorado, Dept Endocrinol, Aurora, CO 80045 USA

[3] Texas Childrens Hosp, Dept Pediat, Baylor Coll Med Educ, Psychol Sect, Houston, TX 77030 USA

[4] Amer Diabet Assoc, Alexandria, VA USA

[5] Daiichi Sankyo, Clin Dev, New York, NY USA

[6] Univ Oklahoma, Coll Med, Dept Pediat, Oklahoma City, OK 73190 USA

[7] Univ Oklahoma, Coll Med, Harold Hamm Diabet Ctr Childrens, Oklahoma City, OK 73190 USA

[8] Indiana Univ Sch Med, Indianapolis, IN 46202 USA

[9] CUNY, Sch Publ Hlth, New York, NY 10021 USA

[10] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

[11] Navajo Area Indian Hlth Serv, Northern Navajo Med Ctr, Pediat & Community Hlth, Shiprock, NM USA

[12] Hlth Sci Ctr Winnipeg, Dept Pediat, Winnipeg, MB, Canada

[13] Yale Sch Med, Dept Pediat Endocrinol, New Haven, CT USA

[14] Yale Sch Med, Yale Ctr Clin Invest, New Haven, CT USA

来源：

DIABETES CARE | 2016年 / 39卷 / 09期

基金：

美国国家卫生研究院; 美国医疗保健研究与质量局;

关键词：

GLYCEMIC CONTROL; SOCIAL DETERMINANTS; INSULIN SENSITIVITY; CARDIOVASCULAR RISK; TREATMENT OPTIONS; ADOLESCENTS; CHILDREN; OBESITY; HEALTH; MELLITUS;

D O I：

10.2337/dc16-1066

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes is a significant and increasing burden in adolescents and young adults. Clear strategies for research, prevention, and treatment of the disease in these vulnerable patients are needed. Evidence suggests that type 2 diabetes in children is different not only from type 1 but also from type 2 diabetes in adults. Understanding the unique pathophysiology of type 2 diabetes in youth, as well as the risk of complications and the psychosocial impact, will enable industry, academia, funding agencies, advocacy groups, and regulators to collectively evaluate both current and future research, treatment, and prevention approaches. This Consensus Report characterizes type 2 diabetes in children, evaluates the fundamental differences between childhood and adult disease, describes the current therapeutic options, and discusses challenges to and approaches for developing new treatments.

引用

页码：1635 / 1642

页数：8

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