New norditerpenoid alkaloids from Scutellaria barbata with cytotoxic activities

被引：28

作者：

Dai, Sheng-Jun ^{[1
]}

Peng, Wei-Bing ^{[2
]}

Shen, Li ^{[2
]}

Zhang, De-Wu ^{[1
]}

Ren, Yan ^{[1
]}

机构：

[1] Yantai Univ, Sch Pharmaceut Sci, Yantai 264005, Peoples R China

[2] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Inst Marine Drug & Food, Qingdao 266003, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2011年 / 25卷 / 11期

关键词：

Scutellaria barbata; Labiatae; norditerpenoid alkaloid; scutebarbatine M-N; cytotoxic activity; NEOCLERODANE DITERPENOID ALKALOIDS; RESISTANT;

D O I：

10.1080/14786410903132464

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new norditerpenoid alkaloids, named scutebarbatines M-N (1 and 2), were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were established on the basis of detailed spectral analyses. In vitro, two new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma and HT29 colorectal carcinoma cells), and gave IC50 values in the range of 3.5-6.3 mu M.

引用

页码：1019 / 1024

页数：6

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