Universal Bound on the Fano Factor in Enzyme Kinetics

被引：69

作者：

Barato, Andre C. ^{[1
]}

Seifert, Udo ^{[1
]}

机构：

[1] Univ Stuttgart, Inst Theoret Phys 2, D-70550 Stuttgart, Germany

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2015年 / 119卷 / 22期

关键词：

STATISTICAL KINETICS; POISSON INDICATOR; MOLECULE; FLUCTUATIONS; DYNAMICS; VELOCITY; SYSTEMS;

D O I：

10.1021/acs.jpcb.5b01918

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The Fano factor, an observable quantifying fluctuations of product generation by a single enzyme, can reveal information about the underlying reaction scheme. A lower bound on this Fano factor that depends on the thermodynamic affinity driving the transformation from substrate to product constrains the number of intermediate states of an enzymatic cycle. So far, this bound has been proven only for a unicyclic network of states. We show that the bound can be extended to arbitrary multicyclic networks, with the Fano factor constraining the largest value of the effective length, which is the ratio between the number of states and the number of products, among all cycles.

引用

页码：6555 / 6561

页数：7

共 25 条

[11] Molecular motors: A theorist's perspective [J].

Kolomeisky, Anatoly B. ;

Fisher, Michael E. .

ANNUAL REVIEW OF PHYSICAL CHEMISTRY, 2007, 58 :675-695

[12] Michaelis-Menten relations for complex enzymatic networks [J].

Kolomeisky, Anatoly B. .

JOURNAL OF CHEMICAL PHYSICS, 2011, 134 (15)

[13] Maximal force exerted by a molecular motor [J].

Koza, Z .

PHYSICAL REVIEW E, 2002, 65 (03) :1-031905

[14] General technique of calculating the drift velocity and diffusion coefficient in arbitrary periodic systems [J].

Koza, Z .

JOURNAL OF PHYSICS A-MATHEMATICAL AND GENERAL, 1999, 32 (44) :7637-7651

[15] A Gallavotti-Cohen-type symmetry in the large deviation functional for stochastic dynamics [J].

Lebowitz, JL ;

Spohn, H .

JOURNAL OF STATISTICAL PHYSICS, 1999, 95 (1-2) :333-365

[16] Recent advances in optical tweezers [J].

Moffitt, Jeffrey R. ;

Chemla, Yann R. ;

Smith, Steven B. ;

Bustamante, Carlos .

ANNUAL REVIEW OF BIOCHEMISTRY, 2008, 77 :205-228

[17] Extracting signal from noise: kinetic mechanisms from a Michaelis-Menten-like expression for enzymatic fluctuations [J].

Moffitt, Jeffrey R. ;

Bustamante, Carlos .

FEBS JOURNAL, 2014, 281 (02) :498-517

[18] Mechanistic constraints from the substrate concentration dependence of enzymatic fluctuations [J].

Moffitt, Jeffrey R. ;

Chemla, Yann R. ;

Bustamante, Carlos .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (36) :15739-15744

[19] Phosphorylation energy hypothesis: Open chemical systems and their biological functions [J].

Qian, Hong .

ANNUAL REVIEW OF PHYSICAL CHEMISTRY, 2007, 58 (113-142) :113-142

[20] Single-molecule experiments in biological physics: methods and applications [J].

Ritort, F. .

JOURNAL OF PHYSICS-CONDENSED MATTER, 2006, 18 (32) :R531-R583

← 1 2 3 →