Mortality in Hematologic Malignancy and Hematopoietic Stem Cell Transplant Patients with Mucormycosis, 2001 to 2009

被引：35

作者：

Hammond, Sarah P. ^{[1
]}

Baden, Lindsey R.

Marty, Francisco M.

机构：

[1] Brigham & Womens Hosp, Div Infect Dis, Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 11期

关键词：

MYCOSES STUDY-GROUP; EUROPEAN-ORGANIZATION; FUNGAL-INFECTIONS; SALVAGE THERAPY; ZYGOMYCOSIS; VORICONAZOLE; POSACONAZOLE; RECIPIENTS; DISEASES; OUTCOMES;

D O I：

10.1128/AAC.00536-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mortality due to mucormycosis is high. We assessed clinical characteristics and mortality among stem cell transplant and hematologic malignancy patients diagnosed with mucormycosis from 2001 to 2009. Thirty patients were diagnosed with probable or proven mucormycosis during the study. Twenty-six were diagnosed premortem, and most were treated with liposomal amphotericin B single-agent antifungal therapy initially. While the initial antifungal and surgical treatment approach remained stable throughout the study period, 6-week mortality significantly declined over time (67% in 2001 to 2003 versus 45% in 2004 to 2006 versus 20% in 2007 to 2009 [P = 0.04]), as did 12-week mortality (78% in 2001 to 2003 versus 55% in 2004 to 2006 versus 20% in 2007 to 2009 [P = 0.01]).

引用

页码：5018 / 5021

页数：4

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