Luminescent Ag(I) scorpionates based on tris(2-pyridyl)phosphine oxide: Synthesis and cytotoxic activity evaluation

被引：26
作者：
Artem'ev, Alexander V. [1 ]
Eremina, Julia A. [1 ,2 ]
Lider, Elizaveta V. [1 ,2 ]
Antonova, Olga V. [1 ]
Vorontsova, Elena V. [3 ]
Bagryanskaya, Irina Yu. [2 ,4 ]
机构：
[1] Russian Acad Sci, Siberian Branch, Nikolaev Inst Inorgan Chem, 3 Akad Lavrentiev Ave, Novosibirsk 630090, Russia
[2] Natl Res Univ, Novosibirsk State Univ, Dept Nat Sci, 2 Pirogova Str, Novosibirsk 630090, Russia
[3] Inst Mol Biol & Biophys, 2-12 Timakova St, Novosibirsk 630117, Russia
[4] Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Akad Lavrentiev Ave, Novosibirsk 630090, Russia
来源：
POLYHEDRON | 2017年 / 138卷
基金：
俄罗斯基础研究基金会;
关键词：
Silver; Scorpionates; Luminescence; Cytotoxic activity; Tris(2-pyridyl)phosphine oxide; UNSUPPORTED SILVER-GERMANIUM; CATALYZED CARBENE INSERTION; ANTIMICROBIAL PROPERTIES; ETHYLENE COMPLEXES; ADDUCTS; LIGANDS; TRIS(PYRAZOLYL)BORATE; CARBONYL; COPPER; DERIVATIVES;
D O I：
10.1016/j.poly.2017.09.041
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
First representatives of Ag(I) scorpionates bearing tris(2-pyridyl)phosphine oxide (Py3P=O), viz. [Ag (Py3P=O)(PPh3)]BE4 (1) and [Ag(Py3P=O)(PPh3)]CIO4 (2), have been synthesized and structurally characterized. X-ray diffraction analysis reveals that the silver atom of 1 is coordinated by Py3P=O and Ph3P ligands in N,N',N"-tripodal and P-monodentate fashions, respectively. The both complexes exhibit significant cytotoxic activity (IC50 being from 11 to 14 mu M) screened in vitro against human larynx carcinoma (Hep-2) cell lines. The luminescent proprieties of the prepared scorpionates are also discussed. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：218 / 224
页数：7
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