N-tritylprolinal:: An efficient building block for the stereoselective synthesis of proline-derived amino alcohols

被引：30

作者：

Bejjani, J ^{[1
]}

Chemla, F ^{[1
]}

Audouin, M ^{[1
]}

机构：

[1] Univ Paris 06, Chim Organ Lab, UMR 7611, F-75252 Paris 05, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 25期

关键词：

D O I：

10.1021/jo034976g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Tritylprolinal (prepared in four steps from L-proline) shows a very high Felkin diastereoselectivity in its reaction with various nucleophiles, leading to a straightforward and highly stereoselective access to syn-proline-derived amino alcohols.

引用

页码：9747 / 9752

页数：6

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