Multicomponent domino reactions in deep eutectic solvent: An efficient strategy to synthesize multisubstituted cyclohexa-1,3-dienamines

被引：51

作者：

Azizi, Najmedin ^{[1
]}

Ahooie, Tahereh Soleymani ^{[2
]}

Hashemi, Mohammad Mahmoudi ^{[2
]}

机构：

[1] Chem & Chem Engn Res Ctr Iran, POB 14335-186, Tehran, Iran

[2] Islamic Azad Univ, Sci & Res Branch, Dept Chem, Tehran, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2017年 / 246卷

基金：

美国国家科学基金会;

关键词：

Multicomponent domino reactions; Deep eutectic solvent; Multisubstituted cyclohexa-1,3-dienamines; Green chemistry; ONE-POT SYNTHESIS; HETEROCYCLIC SCAFFOLDS; ACID; MEDIA; ESTERIFICATION; CATALYSTS; DESIGN; GREEN;

D O I：

10.1016/j.molliq.2017.09.049

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The multicomponent domino reactions of ketones, aldehydes and malononitrile in a deep eutectic solvent (DES) were developed. Urea-choline chloride based DES is effective dual solvents/organocatalysts and affording a series of multisubstituted cyclohexa-1,3-dienamines in good to excellent yields under mild conditions. The DES could be easily recycled several times without appreciable loss of activity. The present protocol offers advantages in terms of environmental sustainability and efficient utilization of natural resources, operational simplicity and short reaction times. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：221 / 224

页数：4

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