Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer

被引：48
作者：
Decock, J. [1 ]
Paridaens, R. [1 ,2 ]
Ye, S. [3 ]
机构：
[1] Katholieke Univ Leuven, Katholieke Univ Leuven Hosp, Dept Oncol, Expt Oncol Lab, Louvain, Belgium
[2] Katholieke Univ Leuven Hosp, Multidisciplinary Breast Ctr, Louvain, Belgium
[3] Univ London, Sch Med, William Harvey Res Inst, Dept Clin Pharmacol, London WC1E 7HU, England
来源：
CLINICAL GENETICS | 2008年 / 73卷 / 03期
关键词：
breast cancer; colorectal cancer; lung cancer; matrix metalloproteinases; polymorphism; SNP; survival; susceptibility;
D O I：
10.1111/j.1399-0004.2007.00946.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The matrix metalloproteinases (MMPs) can degrade various components of the extracellular matrix and are implicated in the development and progression of cancer. There is evidence suggesting an association of MMP gene polymorphisms with cancer susceptibility and/or metastasis. This paper reviews the findings on several single nucleotide polymorphisms in the collagenase, stromelysin and gelatinase genes in lung cancer, breast cancer and colorectal cancer.
引用
收藏
页码：197 / 211
页数：15
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