Assessment of cardiac diastolic dysfunction in HIV-infected people without cardiovascular symptoms in China

被引：21

作者：

Luo, L. ^{[1
]}

Ye, Y. ^{[2
,3
]}

Liu, Z. ^{[1
]}

Zuo, L. ^{[1
]}

Li, Y. ^{[1
]}

Han, Y. ^{[1
]}

Qiu, Z. ^{[1
]}

Li, L. ^{[2
,3
]}

Zeng, Y. ^{[2
,3
]}

Li, T-S ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Infect Dis, Beijing 100730, Peoples R China

[2] Chinese Acad Med Sci, Dept Cardiovasc Dis, Beijing 100730, Peoples R China

[3] Peking Union Med Coll, Beijing 100021, Peoples R China

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2010年 / 21卷 / 12期

关键词：

HIV; HAART; echocardiography; zidovudine; diastolic dysfunction; REVERSE-TRANSCRIPTASE INHIBITORS; POSITIVE PATIENTS; VENTRICULAR DYSFUNCTION; ANTIRETROVIRAL THERAPY; MITOCHONDRIAL-DNA; DISEASE; MEN; ABNORMALITIES; MULTICENTER; IMPACT;

D O I：

10.1258/ijsa.2010.010168

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study assessed cardiac diastolic dysfunction (DD) in HIV-infected subjects without cardiovascular symptoms in China. Eighty-four HIV-infected patients without cardiovascular symptoms were recruited and compared with 30 HIV-negative control subjects. Cardiac DD was evaluated using echocardiography including tissue Doppler imaging. DD was detected in 47.6% of AIDS patients and 42.8% of HIV-positive patients, which was significantly higher than in HIV-negative controls. After logistic regression analysis, HIV infection was independently correlated with cardiac DD (P < 0.05). Among HIV-positive subjects, logistic regression analysis showed that zidovudine exposure was associated with higher prevalence of DD (P < 0.05). Asymptomatic cardiac DD was observed frequently in HIV-infected subjects. HIV infection itself and zidovudine exposure were correlated with a higher prevalence of cardiac DD.

引用

页码：814 / 818

页数：5

共 30 条

[11] A practical approach to the echocardiographic evaluation of diastolic function [J].