Assessment of cardiac diastolic dysfunction in HIV-infected people without cardiovascular symptoms in China

被引：21
作者：
Luo, L. [1 ]
Ye, Y. [2 ,3 ]
Liu, Z. [1 ]
Zuo, L. [1 ]
Li, Y. [1 ]
Han, Y. [1 ]
Qiu, Z. [1 ]
Li, L. [2 ,3 ]
Zeng, Y. [2 ,3 ]
Li, T-S [1 ]
机构：
[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Infect Dis, Beijing 100730, Peoples R China
[2] Chinese Acad Med Sci, Dept Cardiovasc Dis, Beijing 100730, Peoples R China
[3] Peking Union Med Coll, Beijing 100021, Peoples R China
来源：
INTERNATIONAL JOURNAL OF STD & AIDS | 2010年 / 21卷 / 12期
关键词：
HIV; HAART; echocardiography; zidovudine; diastolic dysfunction; REVERSE-TRANSCRIPTASE INHIBITORS; POSITIVE PATIENTS; VENTRICULAR DYSFUNCTION; ANTIRETROVIRAL THERAPY; MITOCHONDRIAL-DNA; DISEASE; MEN; ABNORMALITIES; MULTICENTER; IMPACT;
D O I：
10.1258/ijsa.2010.010168
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This study assessed cardiac diastolic dysfunction (DD) in HIV-infected subjects without cardiovascular symptoms in China. Eighty-four HIV-infected patients without cardiovascular symptoms were recruited and compared with 30 HIV-negative control subjects. Cardiac DD was evaluated using echocardiography including tissue Doppler imaging. DD was detected in 47.6% of AIDS patients and 42.8% of HIV-positive patients, which was significantly higher than in HIV-negative controls. After logistic regression analysis, HIV infection was independently correlated with cardiac DD (P < 0.05). Among HIV-positive subjects, logistic regression analysis showed that zidovudine exposure was associated with higher prevalence of DD (P < 0.05). Asymptomatic cardiac DD was observed frequently in HIV-infected subjects. HIV infection itself and zidovudine exposure were correlated with a higher prevalence of cardiac DD.
引用
收藏
页码：814 / 818
页数：5
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