A novel variant of mouse MATE-1 H+/organic cation antiporter with a long hydrophobic tall

被引：19

作者：

Kobara, Ayumi ^{[1
]}

Hiasa, Miki ^{[1
]}

Matsumoto, Takuya ^{[1
]}

Otsuka, Masato ^{[1
]}

Omote, Hiroshi ^{[1
]}

Moriyama, Yoshinori ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Membrane Biochem, Okayama 7008530, Japan

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2008年 / 469卷 / 02期

基金：

日本学术振兴会;

关键词：

MATE; organic cation transporter; xenobiotic exporter;

D O I：

10.1016/j.abb.2007.10.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammalian multidrug and toxic compound extrusion 1 (MATE1) are polyspecific H+-coupled exporters of organic cations (OCs) and responsible for excretion of metabolic waste products and xenobiotics. Here, we report a novel variant of mouse MATE1, mMATE1b, that has a long carboxyl terminal hydrophobic tail homologous to other MATE1 transporter proteins. Mouse MATE1b mediates tetraethylammonium (TEA) uptake with properties similar to that of mMATE1 and is localized in renal brush border membranes. Thus, mMATE1b is a functional variant of mMATE1 and seems to be the true counterpart to other MATE1 transporters. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：195 / 199

页数：5

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