Development of the one-carbon homologation of a 4-methylcoumarin assisted by in-line FTIR

被引：14

作者：

Horváth, A ^{[1
]}

De Smet, K ^{[1
]}

Ormerod, D ^{[1
]}

Depré, D ^{[1
]}

Pérez-Balado, C ^{[1
]}

Govaerts, T ^{[1
]}

Van den Heuvel, D ^{[1
]}

Schorpion, I ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev, B-2340 Beerse, Belgium

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2005年 / 9卷 / 03期

关键词：

D O I：

10.1021/op049787u

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In-line FTIR was applied as a suitable PAT (process analytical technology) to monitor and control the enolate formation step in the one-carbon homologation process of a 4-methylcoumarin with chloromethyl pivalate. The techniques to determine the endpoint of the reaction and to obtain kinetic and stability data both in THF and DMF as reaction solvent are presented. The valuable chemical data obtained by this PAT was used to support the scale-up of the homologation process.

引用

页码：356 / 359

页数：4

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Watson, DJ ;

Dowdy, ED ;

DePue, JS ;

Kotnis, AS ;

Leung, S ;

O'Reilly, BC .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2004, 8 (04) :616-623

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