Administration of testosterone results in reversible deterioration in Kennedy's disease

被引：18

作者：

Kinirons, P. ^{[1
]}

Rouleau, G. A. ^{[1
]}

机构：

[1] Univ Montreal, Ctr Study Brain Dis, Montreal, PQ H2L 4W5, Canada

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2008年 / 79卷 / 01期

关键词：

D O I：

10.1136/jnnp.2006.101899

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

引用

页码：106 / 107

页数：2

共 6 条

[1] Polyglutamine expansion causes neurodegeneration by altering the neuronal differentiation program [J].

Abou-Sleymane, G ;

Chalmel, F ;

Helmlinger, D ;

Lardenois, A ;

Thibault, C ;

Weber, C ;

Mérienne, K ;

Mandel, JL ;

Poch, O ;

Devys, D ;

Trottier, Y .

HUMAN MOLECULAR GENETICS, 2006, 15 (05) :691-703

[2] Testosterone therapy and the pathogenesis of Kennedy's disease (X-linked bulbospinal muscular atrophy) [J].

Goldenberg, JN ;

Bradley, WG .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1996, 135 (02) :158-161

[3] Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy [J].

Katsuno, M ;

Adachi, H ;

Doyu, M ;

Minamiyama, M ;

Sang, C ;

Kobayashi, Y ;

Inukai, A ;

Sobue, G .

NATURE MEDICINE, 2003, 9 (06) :768-773

[4] Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy [J].

Katsuno, M ;

Adachi, H ;

Kume, A ;

Li, M ;

Nakagomi, Y ;

Niwa, H ;

Sang, C ;

Kobayashi, Y ;

Doyu, M ;

Sobue, G .

NEURON, 2002, 35 (05) :843-854

[5] ANDROGEN RECEPTOR GENE-MUTATIONS IN X-LINKED SPINAL AND BULBAR MUSCULAR-ATROPHY [J].

LASPADA, AR ;

WILSON, EM ;

LUBAHN, DB ;

HARDING, AE ;

FISCHBECK, KH .

NATURE, 1991, 352 (6330) :77-79

[6] Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease [J].

Yamamoto, A ;

Lucas, JJ ;

Hen, R .

CELL, 2000, 101 (01) :57-66

← 1 →