In vitro evaluation of platelet concentrates during storage: Platelet counts and markers of platelet destruction

被引：12

作者：

Apelseth, Torunn O. ^{[1
,2
]}

Hervig, Tor ^{[1
,2
]}

机构：

[1] Haukeland Hosp, N-5021 Bergen, Norway

[2] Univ Bergen, Gades Inst, N-5021 Bergen, Norway

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2007年 / 37卷 / 03期

关键词：

D O I：

10.1016/j.transci.2007.02.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Differences in platelet counts are observed by use of automated haematology analyzers making interlaboratory comparison difficult. Materials and methods: Twenty-eight single-donor platelet concentrates (PCs) were collected. Platelet concentration and markers of platelet destruction were investigated during storage for 11/12 days. Results: Increasing impedance-immunoplatelet ratio was observed during storage, correlating to platelet fragments, large platelets, platelet density and cell-lysis. High variability was observed for optical-immunoplatelet ratio. Conclusion: Immunoplatelet count or correction factor calculated by impedance-immunoplatelet ratio should be used to confirm that platelet unit meets platelet count requirements or to compare results from clinical trials. Optical platelet count is not recommended. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：261 / 268

页数：8

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