SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study

被引:87
作者
Li, E. [1 ]
Assenza, Marco [2 ]
Aydin, Yener [3 ]
Ince, Ilker [3 ]
Ulas, Ali Bilal [3 ]
Motas, Natalia [4 ]
Gulcek, Emre [5 ]
Sedlak, Marian [6 ]
Lima Marson, Fernando Augusto [7 ]
机构
[1] NIHR Global Hlth Res Unit Global Surg, Birmingham, W Midlands, England
[2] Policlin Umberto 1, Rome, Italy
[3] Ataturk Univ, Res & Training Hosp, Sch Med, Erzurum, Turkiye
[4] Inst Oncol Prof Dr Al Trestioreanu, Bucharest, Romania
[5] Gazi Univ, Med Fac Hosp, Ankara, Turkey
[6] L Pasteur Univ Hosp, Kosice, Slovakia
[7] Hosp Univ Sao Francisco Assis Providencia Deus, Braganca Paulista, SP, Brazil
关键词
COVID-19; deep vein thrombosis; pulmonary embolism; SARS-CoV-2; venous thromboembolism;
D O I
10.1111/anae.15563
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (>= 7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARSCoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARSCoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3-6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.
引用
收藏
页码:28 / 39
页数:12
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