Organic-inorganic mesoporous nanocarriers, integrated with biogenic ligands

被引:114
作者
Gu, Jinlou [1 ]
Fan, Wei [1 ]
Shimojima, Atsushi [1 ]
Okubo, Tatsuya [1 ]
机构
[1] Univ Tokyo, Dept Chem Syst Engn, Bunkyo Ku, Tokyo 1138656, Japan
关键词
biomedicine; hybrid materials; mesoporous materials; nanobiotechnotogy; nanocarriers;
D O I
10.1002/smll.200700311
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A novel process for the synthesis of low-submicrometer organic-inorganic mesoporous nanoparticles (MNPs) with Brunauer-Emmett-Teller (BET) with high surface area and large pored volume was analyzed. Cetyltrimethylammonium bromide was dissolved in a solution that contained water and EG with ammonia aqueous solution. LA functionalization was activated by dicyclohexylcarbodiimide and N-hydroxysuccinimide dissolved in dimethylformamide solution with stirring. The generation of cylindrical micelles with a silicate coating (MSCs) initiated the nucleation involving surfactant-silicate interaction, which facilitated cylindrical, micelles with a silicate coating. Observation derived from the experiment implied that particle growth will be driven by surface area of contact between the particle and the surrounding fluid by forming the shape of sphere. The results show that the method is successful in the preparation of low submicrometer organic-inorganic hybrid MNPs.
引用
收藏
页码:1740 / 1744
页数:5
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