Neurotrophin receptors: mediators of life and death

被引：147

作者：

Chao, M ^{[1
]}

Casaccia-Bonnefil, P ^{[1
]}

Carter, B ^{[1
]}

Chittka, A ^{[1
]}

Kong, HY ^{[1
]}

Yoon, SO ^{[1
]}

机构：

[1] Cornell Univ Med Coll, Dept Cell Biol & Anat, New York, NY 10021 USA

来源：

BRAIN RESEARCH REVIEWS | 1998年 / 26卷 / 2-3期

关键词：

NGF; neurotrophic; signal transduction; death; receptor;

D O I：

10.1016/S0165-0173(97)00036-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mechanism of action of NGF has continued to provide a challenging and formidable problem in signal transduction. NGF can bind independently to two different receptors, the trkA tyrosine kinase receptor and the p75 neurotrophin receptor, which are involved in many different signaling events. In addition to promoting cell differentiation survival, NGF can paradoxically be an inducer of cell death. Several receptor mediated mechanisms are proposed to explain how NGF might act as a trophic factor and as a cell killer. The survival and cell death properties of the receptors are dependent upon the relative ratio of receptors and the persistent nature of the signaling events. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：295 / 301

页数：7

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