Zinc exhibits an antidepressant-like effect in the forced swimming test in mice

被引：1
作者：
Kroczka, B
Zieba, A
Dudek, D
Pilc, A
Nowak, G
机构：
[1] Polish Acad Sci, Inst Pharmacol, Dept Neurobiol, PL-31343 Krakow, Poland
[2] Jagiellonian Univ, Coll Med, Dept Psychiat, Krakow, Poland
[3] Jagiellonian Univ, Coll Med, Dept Drug Management, Krakow, Poland
[4] Jagiellonian Univ, Coll Med, Lab Radiol Res, Krakow, Poland
来源：
POLISH JOURNAL OF PHARMACOLOGY | 2000年 / 52卷 / 05期
关键词：
zinc; NMDA receptor; forced swimming test;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of zinc, the NMDA receptor inhibitor, were studied in the forced swimming (Porsolt's) test in mice. Zinc (ZnSO4) at a dose of 30 mg/kg (but not at a dose of 10 mg/kg), similarly to imipramine (30 mg/kg), reduced the immobility time in that test. Moreover, zinc at both doses reduced the locomotor activity. The obtained results indicate that zinc induces an antidepressant-like effect in the forced swimming test. Since zinc reduces the locomotor activity, this antidepressant-like effect is not related to the alteration of general activity.
引用
收藏
页码：403 / 406
页数：4
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