Zinc exhibits an antidepressant-like effect in the forced swimming test in mice

被引：1

作者：

Kroczka, B

Zieba, A

Dudek, D

Pilc, A

Nowak, G

机构：

[1] Polish Acad Sci, Inst Pharmacol, Dept Neurobiol, PL-31343 Krakow, Poland

[2] Jagiellonian Univ, Coll Med, Dept Psychiat, Krakow, Poland

[3] Jagiellonian Univ, Coll Med, Dept Drug Management, Krakow, Poland

[4] Jagiellonian Univ, Coll Med, Lab Radiol Res, Krakow, Poland

来源：

POLISH JOURNAL OF PHARMACOLOGY | 2000年 / 52卷 / 05期

关键词：

zinc; NMDA receptor; forced swimming test;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of zinc, the NMDA receptor inhibitor, were studied in the forced swimming (Porsolt's) test in mice. Zinc (ZnSO4) at a dose of 30 mg/kg (but not at a dose of 10 mg/kg), similarly to imipramine (30 mg/kg), reduced the immobility time in that test. Moreover, zinc at both doses reduced the locomotor activity. The obtained results indicate that zinc induces an antidepressant-like effect in the forced swimming test. Since zinc reduces the locomotor activity, this antidepressant-like effect is not related to the alteration of general activity.

引用

页码：403 / 406

页数：4

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