Rhazinilam-leuconolam family of natural products: a half century of total synthesis

被引：16
作者：
Sirindil, Fatih [1 ]
Weibel, Jean-Marc [1 ]
Pale, Patrick [1 ]
Blanc, Aurelien [1 ]
机构：
[1] Univ Strasbourg, Inst Chim, Lab Synth Reactivite Organ & Catalyse, UMR 7177 CNRS, 4 Rue Blaise Pascal, F-67070 Strasbourg, France
来源：
NATURAL PRODUCT REPORTS | 2022年 / 39卷 / 08期
关键词：
H BOND FUNCTIONALIZATION; ENANTIOSELECTIVE TOTAL SYNTHESES; ASYMMETRIC HECK; CONCISE SYNTHESIS; FORMAL SYNTHESIS; ALKALOIDS; (-)-RHAZINILAM; CYCLIZATION; (-)-LEUCONOLAM; LEUCONODINES;
D O I：
10.1039/d2np00026a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Covering: 1972 to 2021 The rhazinilam family of natural products exhibits a main structure with a stereogenic quaternary carbon and a tetrahydroindolizine core imbedded within a 9-membered macrocycle, imposing axial chirality. This unique architecture combined with their taxol-like antimitotic activities have attracted various attention, especially from synthetic chemists, notably in the past decade. The present review describes the known total and formal syntheses of the members of the rhazinilam family (rhazinilam, rhazinal, leuconolam and kopsiyunnanines), according to the strategy developed.
引用
收藏
页码：1574 / 1590
页数：17
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