Id proteins in cell growth and tumorigenesis

被引：278

作者：

Sikder, HA ^{[1
]}

Devlin, MK ^{[1
]}

Dunlap, S ^{[1
]}

Ryu, B ^{[1
]}

Alani, RM ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprhens Canc Ctr, Baltimore, MD 21231 USA

来源：

CANCER CELL | 2003年 / 3卷 / 06期

关键词：

D O I：

10.1016/S1535-6108(03)00141-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Since the gene encoding Id1 was cloned in 1990, Id proteins have been implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. The development of knockout and transgenic animal models for many members of the Id gene family has been particularly useful in sorting out the biologic relevance of these genes and their expression during normal development, malignant transformation, and tumor progression. Here we review the current understanding of Id gene function, the biologic consequences of Id gene expression, and the implications for Id gene regulation of cell growth and tumorigenesis.

引用

页码：525 / 530

页数：6

共 59 条

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