Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder

被引：29

作者：

Zhu, Jiang ^{[1
,2
]}

Hua, Xueying ^{[1
,3
]}

Yang, Ting ^{[1
,2
]}

Guo, Min ^{[1
,2
]}

Li, Qiu ^{[1
,2
]}

Xiao, Lu ^{[1
,2
]}

Li, Ling ^{[4
]}

Chen, Jie ^{[1
,2
]}

Li, Tingyu ^{[1
,2
,5
]}

机构：

[1] Chongqing Med Univ, Childrens Nutr Res Ctr, Chongqing Key Lab Childhood Nutr & Hlth, Childrens Hosp, Chongqing 400014, Peoples R China

[2] Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ, China Int Sci & Technol Cooperat Base Child Dev &, Key Lab Child Dev & Disorders, Chongqing 400014, Peoples R China

[3] Chongqing Med Univ, Affiliated Children Hosp, Dept Neonatol, Chongqing 400014, Peoples R China

[4] Hainan Women & Childrens Med Ctr, Dept Children Rehabil, Hainan 570100, Peoples R China

[5] Chongqing Med Univ, Childrens Hosp, Childrens Nutr Res Ctr, Key Lab,Minist Educ, 136 Zhongshan Er Rd, Chongqing 400014, Peoples R China

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2022年 / 52卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Autism; Metabolomics; Metabolism; Vitamin; Symptoms; Children; TRYPTOPHAN-METABOLISM; OXIDATIVE STRESS; RETINOIC ACID; MICROBIOTA; HOMOCYSTEINE; BIOMARKER; FOLATE; SEROTONIN; MARKERS;

D O I：

10.1007/s10803-021-05066-w

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate the gut metabolomic profiles of autistic children and to analyze potential interaction between gut metabolites with autistic symptoms and neurodevelopment levels. We involved 120 autistic and 60 neurotypical children. Autistic symptoms and neurodevelopment levels were assessed. Fecal samples were analyzed using untargeted liquid chromatography-tandem mass spectrometry methods. Our results showed the metabolic disturbances of autistic children involved in multiple vitamin and amino acid metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine-methionine metabolism, and vitamin digestion and absorption. Differential gut metabolites were correlated to autistic symptoms and neurodevelopment levels. Our findings improved the understanding of the perturbations of metabolome networks in autism.

引用

页码：3116 / 3128

页数：13

共 54 条

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