Functional Cognitive Disorder: Diagnostic Challenges and Future Directions

被引:26
作者
Pennington, Catherine [1 ,2 ]
Ball, Harriet [1 ]
Swirski, Marta [1 ]
机构
[1] Univ Bristol, ReMemBr Grp, Bristol Brain Ctr, Southmead Hosp, Southmead Rd, Bristol BS10 5NB, Avon, England
[2] Univ Edinburgh, Ctr Dementia Prevent, 9A Bioquarter,9 Little France Rd, Edinburgh EH16 4UX, Midlothian, Scotland
关键词
functional cognitive disorder; neurodegeneration; mild cognitive impairment; functional neurological disorder cognition; REVERSION; DECLINE;
D O I
10.3390/diagnostics9040131
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Functional cognitive disorder describes patients with persistent, troublesome subjective cognitive complaints that are inconsistent with a recognized disease process, and where significant discrepancies are found between subjective and objectively observed cognitive functioning. The etiology is heterogeneous and potentially related to underlying psychological factors. Making a diagnosis of functional cognitive disorder can be challenging and there is the potential for misdiagnosis of early-stage neurodegeneration. We compared neuropsychological findings in three groups: functional cognitive disorder (FCD), mild cognitive impairment (MCI), and healthy controls. Participants were recruited from the ReMemBr Group Clinic, North Bristol NHS Trust, and via Join Dementia Research. Both the FCD and MCI groups showed elevated prospective and retrospective memory symptom scores. Performance on the Montreal cognitive assessment was equivalent in the FCD and MCI groups, both being impaired compared with the controls. The FCD group was younger than those with MCI. We discuss challenges and controversies in the diagnosis of functional cognitive disorder, alongside illustrative cases and proposals for areas of research priority.
引用
收藏
页数:8
相关论文
共 20 条
[1]   Effects of MCI subtype and reversion on progression to dementia in a community sample [J].
Aerts, Liesbeth ;
Heffernan, Megan ;
Kochan, Nicole A. ;
Crawford, John D. ;
Draper, Brian ;
Trollor, Julian N. ;
Sachdev, Perminder S. ;
Brodaty, Henry .
NEUROLOGY, 2017, 88 (23) :2225-2232
[2]   Disability, distress and unemployment in neurology outpatients with symptoms 'unexplained by organic disease' [J].
Carson, A. ;
Stone, J. ;
Hibberd, C. ;
Murray, G. ;
Duncan, R. ;
Coleman, R. ;
Warlow, C. ;
Roberts, R. ;
Pelosi, A. ;
Cavanagh, J. ;
Matthews, K. ;
Goldbeck, R. ;
Hansen, C. ;
Sharpe, M. .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2011, 82 (07) :810-813
[3]   The Prospective and Retrospective Memory Questionnaire (PRMQ): Normative data and latent structure in a large non-clinical sample [J].
Crawford, JR ;
Smith, G ;
Maylor, EA ;
Della Sala, S ;
Logie, RH .
MEMORY, 2003, 11 (03) :261-275
[4]   Mild Cognitive Impairment that Does Not Progress to Dementia: A Population-Based Study [J].
Ganguli, Mary ;
Jia, Yichen ;
Hughes, Tiffany F. ;
Snitz, Beth E. ;
Chang, Chung-Chou H. ;
Berman, Sarah B. ;
Sullivan, Kevin J. ;
Kamboh, M. Ilyas .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2019, 67 (02) :232-238
[5]   Reversion from mild cognitive impairment to normal or near-normal cognition [J].
Koepsell, Thomas D. ;
Monsell, Sarah E. .
NEUROLOGY, 2012, 79 (15) :1591-1598
[6]   Dual diagnosis of epilepsy and psychogenic nonepileptic seizures: Systematic review and meta-analysis of frequency, correlates, and outcomes [J].
Kutlubaev, Mansur A. ;
Xu, Ying ;
Hackett, Maree L. ;
Stone, Jon .
EPILEPSY & BEHAVIOR, 2018, 89 :70-78
[7]   Memory-related subjective cognitive symptoms in the adult population: Prevalence and associated factors - results of the LIFE-Adult-Study [J].
Luck T. ;
Roehr S. ;
Rodriguez F.S. ;
Schroeter M.L. ;
Witte A.V. ;
Hinz A. ;
Mehnert A. ;
Engel C. ;
Loeffler M. ;
Thiery J. ;
Villringer A. ;
Riedel-Heller S.G. .
BMC Psychology, 6 (1)
[8]   Rates of Abnormally Low TOPF Word Reading Scores in Individuals Failing Versus Passing Performance Validity Testing [J].
Martin, Phillip K. ;
Schroeder, Ryan W. ;
Wyman-Chick, Kathryn A. ;
Hunter, Ben P. ;
Heinrichs, Robin J. ;
Baade, Lyle E. .
ASSESSMENT, 2018, 25 (05) :640-652
[9]  
McWhirter L., 2019, IMPROVING DIAGNOSIS
[10]  
Merwick A, 2008, Int MS J, V15, P47