Vitamin D in the prevention and treatment of type-2 diabetes and associated diseases: a critical view during COVID-19 time

被引：10

作者：

Falalyeyeva, Tetyana ^{[1
]}

Komisarenko, Iuliia ^{[2
]}

Yanchyshyn, Andrii ^{[3
]}

Kovalchuk, Oleksandr ^{[1
,3
]}

Lozko, Yuliia ^{[3
]}

Tsyryuk, Olena ^{[1
]}

Fagoonee, Sharmila ^{[4
]}

Kobyliak, Nazarii ^{[2
,5
]}

机构：

[1] Taras Shevchenko Natl Univ Kyiv, Educ & Sci Ctr, Inst Biol & Med, Volodymyrska Str 64-13, UA-01601 Kiev, Ukraine

[2] Bogomolets Natl Med Univ, Dept Endocrinol, Kiev, Ukraine

[3] Bogomolets Natl Med Univ, Dept Descript & Clin Anat, Kiev, Ukraine

[4] Mol Biotechnol Ctr, Inst Biostruct & Bioimaging CNR, Turin, Italy

[5] Lab Pathol CSD Hlth Care, Kiev, Ukraine

来源：

MINERVA BIOTECHNOLOGY AND BIOMOLECULAR RESEARCH | 2021年 / 33卷 / 02期

关键词：

Vitamin D; Diabetes mellitus; type; 2; Non-alcoholic fatty liver disease; FATTY LIVER-DISEASE; D DEFICIENCY; INSULIN-RESISTANCE; D SUPPLEMENTATION; DOUBLE-BLIND; NONALCOHOLIC STEATOHEPATITIS; CARDIOVASCULAR-DISEASE; MOLECULAR-MECHANISMS; 25-HYDROXYVITAMIN D; GLYCEMIC CONTROL;

D O I：

10.23736/S2724-542X.21.02766-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Vitamin D deficiency has been recognized as a pandemic with many negative health consequences in many countries. Today the mechanisms of anti-inflammatory and hepatoprotective action of vitamin D-3 (cholecalciferol) and in general the scientific justification for its effective use in the clinic of type-2 diabetes (T2D) is actively studied in the scientific literature. We performed a review evaluating, that the treatment with vitamin D-3 may increase the chances for successful convalescence: reduction of inflammation and hepatic steatosis; an increase of glycemic control and insulin sensitivity. The above-mentioned issue necessitates a deep and comprehensive study of an important scientific problem, which is the need for clinical justification of the effectiveness of vitamin D-3 for the prevention and correction of metabolic disorders and structural and functional changes in the liver in T2D.

引用

页码：65 / 75

页数：11

共 100 条

[11] Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos Nutrition and Liver Study [J].

Bedogni, G ;

Miglioli, L ;

Masutti, F ;

Tiribelli, C ;

Marchesini, G ;

Bellentani, S .

HEPATOLOGY, 2005, 42 (01) :44-52

[12] Vitamin D Deficiency-Induced Muscle Wasting Occurs through the Ubiquitin Proteasome Pathway and Is Partially Corrected by Calcium in Male Rats [J].

Bhat, Mehrajuddin ;

Kalam, Ramesh ;

Qadri, Syed S. Y. H. ;

Madabushi, Seshacharyulu ;

Ismail, Ayesha .

ENDOCRINOLOGY, 2013, 154 (11) :4018-4029

[13] Vitamin D Metabolism, Mechanism of Action, and Clinical Applications [J].

Bikle, Daniel D. .

CHEMISTRY & BIOLOGY, 2014, 21 (03) :319-329

[14] Expression of 25-hydroxyvitamin D3-1α-hydroxylase in pancreatic islets [J].

Bland, R ;

Markovic, D ;

Hills, CE ;

Hughes, SV ;

Chan, SLF ;

Squires, PE ;

Hewison, M .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2004, 89-90 (1-5) :121-125

[15] Metabolically Healthy Obesity [J].

Blueher, Matthias .

ENDOCRINE REVIEWS, 2020, 41 (03) :405-420

[16] Association between primary hyperparathyroidism and increased body weight: A meta-analysis [J].

Bolland, MJ ;

Grey, AB ;

Gamble, GD ;

Reid, IR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (03) :1525-1530

[17] Cellular and molecular mechanisms of muscle atrophy [J].

Bonaldo, Paolo ;

Sandri, Marco .

DISEASE MODELS & MECHANISMS, 2013, 6 (01) :25-39

[18] Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action [J].

Bril, Fernando ;

Cusi, Kenneth .

DIABETES CARE, 2017, 40 (03) :419-430

[19] NAFLD: A multisystem disease [J].

Byrne, Christopher D. ;

Targher, Giovanni .

JOURNAL OF HEPATOLOGY, 2015, 62 :S47-S64

[20]

Chawla R, 2020, INT J DIABETES DEV C, V40, pS1, DOI [10.1007/s13410-020-00819-2, 10.4103/ijem.IJEM_225_20]

← 1 2 3 4 5 6 7 8 9 10 →