Vitamin D in the prevention and treatment of type-2 diabetes and associated diseases: a critical view during COVID-19 time

被引：10

作者：

Falalyeyeva, Tetyana ^{[1
]}

Komisarenko, Iuliia ^{[2
]}

Yanchyshyn, Andrii ^{[3
]}

Kovalchuk, Oleksandr ^{[1
,3
]}

Lozko, Yuliia ^{[3
]}

Tsyryuk, Olena ^{[1
]}

Fagoonee, Sharmila ^{[4
]}

Kobyliak, Nazarii ^{[2
,5
]}

机构：

[1] Taras Shevchenko Natl Univ Kyiv, Educ & Sci Ctr, Inst Biol & Med, Volodymyrska Str 64-13, UA-01601 Kiev, Ukraine

[2] Bogomolets Natl Med Univ, Dept Endocrinol, Kiev, Ukraine

[3] Bogomolets Natl Med Univ, Dept Descript & Clin Anat, Kiev, Ukraine

[4] Mol Biotechnol Ctr, Inst Biostruct & Bioimaging CNR, Turin, Italy

[5] Lab Pathol CSD Hlth Care, Kiev, Ukraine

来源：

MINERVA BIOTECHNOLOGY AND BIOMOLECULAR RESEARCH | 2021年 / 33卷 / 02期

关键词：

Vitamin D; Diabetes mellitus; type; 2; Non-alcoholic fatty liver disease; FATTY LIVER-DISEASE; D DEFICIENCY; INSULIN-RESISTANCE; D SUPPLEMENTATION; DOUBLE-BLIND; NONALCOHOLIC STEATOHEPATITIS; CARDIOVASCULAR-DISEASE; MOLECULAR-MECHANISMS; 25-HYDROXYVITAMIN D; GLYCEMIC CONTROL;

D O I：

10.23736/S2724-542X.21.02766-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Vitamin D deficiency has been recognized as a pandemic with many negative health consequences in many countries. Today the mechanisms of anti-inflammatory and hepatoprotective action of vitamin D-3 (cholecalciferol) and in general the scientific justification for its effective use in the clinic of type-2 diabetes (T2D) is actively studied in the scientific literature. We performed a review evaluating, that the treatment with vitamin D-3 may increase the chances for successful convalescence: reduction of inflammation and hepatic steatosis; an increase of glycemic control and insulin sensitivity. The above-mentioned issue necessitates a deep and comprehensive study of an important scientific problem, which is the need for clinical justification of the effectiveness of vitamin D-3 for the prevention and correction of metabolic disorders and structural and functional changes in the liver in T2D.

引用

页码：65 / 75

页数：11

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