共 52 条
Nanoparticle-Functionalized Porous Polymer Monolith Detection Elements for Surface-Enhanced Raman Scattering
被引:98
作者:
Liu, Jikun
[2
]
White, Ian
[1
]
DeVoe, Don L.
[1
,2
]
机构:
[1] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA
[2] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA
基金:
美国国家卫生研究院;
关键词:
SINGLE-MOLECULE;
GOLD NANOPARTICLES;
SILVER;
SPECTROSCOPY;
SERS;
BRADYKININ;
PROTEINS;
CHANNELS;
CHIP;
TOOL;
D O I:
10.1021/ac102932d
中图分类号:
O65 [分析化学];
学科分类号:
070302 ;
081704 ;
摘要:
The wuse of porous polymer monoliths functionalized with silver nanoparticles is introduced in this work for high-sensitivity surface-enhanced Raman scattering (SERS) detection. Preparation of the SERS detection elements is a simple process comprising the synthesis of a discrete polymer monolith section within a silica capillary, followed by physically trapping silver nanoparticle aggregates within the monolith matrix. A SERS detection limit of 220 fmol for Rhodamine 6G is demonstrated, with excellent signal stability over a 24 h period. The capability of the SERS-active monolith for label-free detection of biomolecules was demonstrated by measurements of bradykinin and cyctochrome c. The SERS-active monoliths can be readily integrated into miniaturized micrototal-analysis systems for online and label-free detection for a variety of biosensing,, bioanalytical, and biomedical applications.
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页码:2119 / 2124
页数:6
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