Interpretation of Biochemical Tests Using the Reference Change Value in Monitoring Adverse Effects of Oral Isotretinoin in 102 Ethnic Turkish Patients

被引：9

作者：

Bugdayci, Guler ^{[1
]}

Polat, Mualla ^{[2
]}

Oguzman, Hamdi ^{[1
]}

Cinpolat, Havva Yasemin ^{[1
]}

机构：

[1] Abant Izzet Baysal Univ, Fac Med, Dept Biochem, Bolu, Turkey

[2] Abant Izzet Baysal Univ, Fac Med, Dept Dermatol, Bolu, Turkey

来源：

LABORATORY MEDICINE | 2016年 / 47卷 / 03期

关键词：

isotretinoin; acne vulgaris; references values; side effects; data interpretation; clinical chemistry test; BIOLOGICAL VARIATIONS; LABORATORY DATA; PLASMA-LIPIDS; THERAPY; NEED;

D O I：

10.1093/labmed/lmw024

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: The aim of this study was to model the use of reference change values (RCVs) for the follow-up of 4 parameters of patients using oral isotretinoin which is gaining widespread popularity for monitoring the side effects of the treatment. Method: 102 patients received 30 mg/day oral isotretinoin for 24 weeks for the diagnosis of acne vulgaris. Results: Repetitive measurements of the patients were interpreted with RCVs, after comparing the first and second doses based on RCVs: TC, TG, AST and ALT results increased in 12%, 20%, 14% and 12% of the patients respectively. When the first dose was compared with the last dose, the increases were 20%, 29%, 22% and 18% respectively interpreted as significant changes based on laboratory medicine. Conclusions: A more sensitive follow-up is possible in the monitorization of adverse effects by using RCVs method.

引用

页码：213 / 219

页数：7

共 26 条

[1] Weekly and 90-Minute Biological Variations in Cardiac Troponin T and Cardiac Troponin I in Hemodialysis Patients and Healthy Controls [J].

Aakre, Kristin M. ;

Roraas, Thomas ;

Petersen, Per Hyltoft ;

Svarstad, Einar ;

Sellevoll, Hilde ;

Skadberg, Oyvind ;

Saele, Kristin ;

Sandberg, Sverre .

CLINICAL CHEMISTRY, 2014, 60 (06) :838-847

[2] Analysis of laboratory data in acne patients treated with isotretinoin: is there really a need to perform routine laboratory tests? [J].

Alcalay, J ;

Landau, M ;

Zucker, A .

JOURNAL OF DERMATOLOGICAL TREATMENT, 2001, 12 (01) :9-12

[3] A proposed set of new guidelines for routine blood tests during isotretinoin therapy for acne vulgaris [J].

Altman, RS ;

Altman, LJ ;

Altman, JS .

DERMATOLOGY, 2002, 204 (03) :232-235

[4]

[Anonymous], DES BIOL VAR DAT SPE

[5]

[Anonymous], COMM TERM CRIT ADV E

[6] Long term reference change value of creatinine in HIV-positive patients with anti-retroviral therapy: A new tool in clinical practice [J].

Badiou, S. ;

Cournil, A. ;

Toubal, S. ;

Bargnoux, A. S. ;

Dupuy, A. M. ;

Fernandez, C. ;

Peyriere, H. ;

Reynes, J. ;

Cristol, J. P. .

CLINICAL BIOCHEMISTRY, 2015, 48 (09) :622-624

[7] ISOTRETINOIN THERAPY FOR ACNE-VULGARIS - A REEVALUATION OF THE NEED FOR MEASUREMENTS OF PLASMA-LIPIDS AND LIVER-FUNCTION TESTS [J].

BARTH, JH ;

MACDONALDHULL, SP ;

MARK, J ;

JONES, RG ;

CUNLIFFE, WJ .

BRITISH JOURNAL OF DERMATOLOGY, 1993, 129 (06) :704-707

[8] CHANGES IN PLASMA-LIPIDS AND LIPOPROTEINS DURING ISOTRETINOIN THERAPY FOR ACNE [J].

BERSHAD, S ;

RUBINSTEIN, A ;

PATERNITI, JR ;

LE, NA ;

POLIAK, SC ;

HELLER, B ;

GINSBERG, HN ;

FLEISCHMAJER, R ;

BROWN, WV .

NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (16) :981-985

[9] The Use of Reference Change Values in Clinical Laboratories [J].

Bugdayci, Guler ;

Oguzman, Hamdi ;

Arattan, Havva Yasemin ;

Sasmaz, Guler .

CLINICAL LABORATORY, 2015, 61 (3-4) :251-257

[10] A systematic review of data on biological variation for alanine aminotransferase, aspartate aminotransferase and γ-glutamyl transferase [J].

Carobene, Anna ;

Braga, Federica ;

Roraas, Thomas ;

Sandberg, Sverre ;

Bartlett, William A. .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2013, 51 (10) :1997-2007

← 1 2 3 →