Highly diastereoselective addition of cinnamylzinc derivatives to α-chiral carbonyl compounds

被引：25
|
作者：
Dunet, Guillaume [1 ]
Mayer, Peter [1 ]
Knochel, Paul [1 ]
机构：
[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 01期
关键词：
D O I：
10.1021/ol702607t
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Cinnamylzinc reagents react with cyclic and acyclic a-chiral ketones under very mild conditions (-78 degrees C, 1 h), yielding the corresponding homoallylic alcohols bearing three adjacent stereocenters with high diastereoselectivity. An extension of this reaction to enantioenriched alpha-chiral ketones is also described.
引用
收藏
页码：117 / 120
页数：4
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