Early age onset colorectal cancer

被引：17
作者：
Patel, Swati G. [1 ]
Murphy, Caitlin C. [2 ]
Lieu, Christopher H. [3 ]
Hampel, Heather [4 ]
机构：
[1] Univ Colorado, Div Gastroenterol & Hepatol, Rocky Mt Reg Vet Affairs Med Ctr, Anschutz Med Campus, Aurora, CO 80045 USA
[2] Univ Texas Southwestern Med Ctr Dallas, Dept Populat & Data Sci, Div Epidemiol, Dallas, TX 75390 USA
[3] Univ Colorado, Div Med Oncol, Gastrointestinal Med Oncol, Anschutz Med Campus, Aurora, CO USA
[4] Ohio State Univ, Ctr Comprehens Canc, Div Human Genet, Biospecimen Res, Columbus, OH 43210 USA
来源：
NOVEL APPROACHES TO COLORECTAL CANCER | 2021年 / 151卷
关键词：
SUSCEPTIBILITY GENE-MUTATIONS; SOCIETY TASK-FORCE; YOUNG-ONSET; FAMILY-HISTORY; LYNCH SYNDROME; COLON-CANCER; RISK-FACTORS; DIABETES-MELLITUS; POOLED ANALYSIS; 1ST-DEGREE RELATIVES;
D O I：
10.1016/bs.acr.2021.03.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The incidence and mortality associated with colorectal cancer (CRC) diagnosed in patients under the age of 50 have been steadily increasing. The exact etiology of these epidemiologic trends is unclear. This chapter will provide a comprehensive review on the topic of early age onset colorectal cancer (EAO-CRC), defined as colorectal cancer (CRC) diagnosed in patients under the age of 50. Topics reviewed will include the epidemiology of EAO-CRC around the world, clinical and pathological features of EAO-CRC in contrast to later age onset CRC (CRC diagnosed on those over the age of 50) and the observed molecular and somatic characteristics. This chapter will review the etiologies to EAO-CRC and the established, as well as proposed risk factors for disease. Evidence-based approaches to prevention, early detection, treatment and survivorship will be presented.
引用
收藏
页码：1 / 37
页数：37
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