Synthesis of (Z)-α-Trifluoromethyl Alkenyl Triflate: A Scaffold for Diverse Trifluoromethylated Species

被引：29

作者：

Zhao, Yilong ^{[1
]}

Zhou, Yuhan ^{[1
]}

Liu, Juan ^{[1
]}

Yang, Dongmei ^{[1
]}

Tao, Liang ^{[1
]}

Liu, Yang ^{[1
]}

Dong, Xiaoliang ^{[1
]}

Liu, Jianhui ^{[2
]}

Qu, Jingping ^{[1
]}

机构：

[1] Dalian Univ Technol, Sch Pharmaceut Sci & Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

[2] Dalian Univ Technol, Sch Petr & Chem Engn, Panjin 124221, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 11期

基金：

中国国家自然科学基金;

关键词：

COPPER-CATALYZED TRIFLUOROMETHYLATION; CONTAINING INTERNAL ALKYNES; CROSS-COUPLING REACTION; ONE-POT SYNTHESIS; STEREOCONTROLLED SYNTHESIS; ASYMMETRIC-SYNTHESIS; PRACTICAL SYNTHESIS; EFFICIENT SYNTHESIS; VINYLBORONIC ACIDS; PALLADIUM;

D O I：

10.1021/acs.joc.6b00855

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of (Z) selective a-trifluoromethyl alkenyl triflates is described. As an important fluorinated building block, it is utilized successfully for the synthesis of various trifluoromethyl derivatives such as diarylethylenes, enynes, alkynes, and benzofurans.

引用

页码：4797 / 4806

页数：10

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