Novel, One-Pot, Three-Component Route to Indol-3-yl Substituted Spirooxindole Derivatives

被引：51

作者：

Chen, Tao ^{[1
]}

Xu, Xiao-Ping ^{[1
]}

Ji, Shun-Jun ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2010年 / 12卷 / 05期

基金：

中国国家自然科学基金;

关键词：

CERIC AMMONIUM-NITRATE; MULTICOMPONENT REACTIONS; BISINDOLE ALKALOIDS; EFFICIENT SYNTHESIS; FACILE SYNTHESIS; MARINE SPONGE; CYTOTOXICITY EVALUATION; ORGANIC-REACTIONS; ANTITUMOR AGENTS; A-D;

D O I：

10.1021/cc100064c

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A simple and efficient approach to the synthesis of a novel series of polysubstituted 6'-(1H-indol-3-yl)-1',7'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-b]pyridine]-2-one derivatives in high yields was developed from a one-pot, three-component reaction of 3-cyanoacetyl indoles, isatins, and 1H-pyrazol-5-amines in H(2)O/HOAc.

引用

页码：659 / 663

页数：5

共 70 条

[1] Synthesis and evaluation of some new spiro indoline-based heterocycles as potentially active antimicrobial agents [J].