Novel gold(I) 7-azacoumarin complex:: Synthesis, structure, optical properties, and cytotoxic effects

被引：17

作者：

Casas, Jose S. ^{[1
]}

Castellano, Eduardo E.

Couce, Mari A. D.

Crespo, Olga

Ellena, Javier

Laguna, Antonio

Sanchez, Agustin

Sordo, Jose

Taboada, Carmen

机构：

[1] Univ Santiago de Compostela, Fac Farm, Dept Quim Inorgan, Santiago De Compostela 15782, Spain

[2] Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP, Brazil

[3] Univ vigo, Fac Ciencias, Dept Quim Inorgan, Vigo 36310, Spain

[4] Univ Zaragoza, Fac Ciencias, Dept Quim Inorgan, CSIC,Inst Ciencias Mat Aragon, E-50009 Zaragoza, Spain

来源：

INORGANIC CHEMISTRY | 2007年 / 46卷 / 16期

关键词：

D O I：

10.1021/ic700861a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A mixture of pyridoxalrhodanine, triethylphosphinegold(I) chloride, and sodium methoxide in methanol unexpectedly afforded the azacoumarin complex [Au(TS)(PEt3)] [HTS = 5-(hydroxymethyl)-8-methyl-3-thiol-7-azacoumarin], which was characterized by X-ray diffractometry. Its crystals consist of independent molecules in which the metal atom is bound to the azacoumarin [Au-S = 2.9458(18) A] and the phosphine [Au-P = 2.262(2) angstrom] in an almost linear arrangement [P1-Au1-S1 = 176.93(7)degrees]. The complex showed better in vitro antitumor activity than cisplatin against the cisplatin-resistant cell line A2780cis.

引用

页码：6236 / 6238

页数：3

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