Exceptionally widespread nanomachines composed of type IV pilins: the prokaryotic Swiss Army knives

被引：182

作者：

Berry, Jamie-Lee ^{[1
]}

Pelicic, Vladimir ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, MRC Ctr Mol Bacteriol & Infect, London SW7 2AZ, England

来源：

FEMS MICROBIOLOGY REVIEWS | 2015年 / 39卷 / 01期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

type IV pilus; type II secretion system; archaellum; class III signal peptide; prepilin peptidase; II SECRETION SYSTEM; ENTEROPATHOGENIC ESCHERICHIA-COLI; TOXIN-COREGULATED-PILUS; EXTRACELLULAR PROTEIN SECRETION; GRAM-NEGATIVE BACTERIA; OUTER-MEMBRANE PROTEIN; BUNDLE-FORMING-PILUS; PSEUDOMONAS-AERUGINOSA PILI; UNIQUE MOTILITY STRUCTURE; AMINO-ACID SUBSTITUTIONS;

D O I：

10.1093/femsre/fuu001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Prokaryotes have engineered sophisticated surface nanomachines that have allowed them to colonize Earth and thrive even in extreme environments. Filamentous machineries composed of type IV pilins, which are associated with an amazing array of properties ranging from motility to electric conductance, are arguably the most widespread since distinctive proteins dedicated to their biogenesis are found in most known species of prokaryotes. Several decades of investigations, starting with type IV pili and then a variety of related systems both in bacteria and archaea, have outlined common molecular and structural bases for these nanomachines. Using type IV pili as a paradigm, we will highlight in this review common aspects and key biological differences of this group of filamentous structures.

引用

页码：134 / 154

页数：21

共 250 条

[1] Substitutions in the N-terminal alpha helical spine of Neisseria gonorrhoeae pilin affect type IV pilus assembly, dynamics and associated functions [J].