Human housekeeping genes are compact

被引：545
作者：
Eisenberg, E [1 ]
Levanon, EY [1 ]
机构：
[1] Compugen Ltd, IL-69512 Tel Aviv, Israel
来源：
TRENDS IN GENETICS | 2003年 / 19卷 / 07期
关键词：
D O I：
10.1016/S0168-9525(03)00140-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We identify a set of 575 human genes that are expressed in all conditions tested in a publicly available database of microarray results. Based on this common occurrence, the set is expected to be rich in 'housekeeping' genes, showing constitutive expression in all tissues. We compare selected aspects of their genomic structure with a set of background genes. We find that the introns, untranslated regions and coding sequences of the housekeeping genes are shorter, indicating a selection for compactness in these genes.
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页码：362 / 365
页数：4
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