The dynamics of NF-κB pathway regulated by circadian clock

The circadian clock regulates many physiological parameters involving immune response to infectious agents, which is mediated by activation of the transcription factor NF-kappa B. Thus, understanding the NF-kappa B dynamics regulated by circadian clocks will help in developing better therapeutics. To this end, we proposed a detailed model in the present work on the basis of understanding inflammatory response under control from circadian clocks. Our results show that the frequencies and amplitudes of the NF-kappa B oscillation are dependent on the strength and modes of coupling to circadian clock. This circadian control of NF-kappa B pathway can therefore serve as a useful mechanism in keeping the system in check and controlling inflammatory response induced by infection and other agents. The results are consistent with earlier experimental findings. (C) 2014 Elsevier Inc. All rights reserved.